Abstract
Cancer is one of the oldest diseases known to man, being one of the leading causes of death worldwide. Modeling this complex pathology and contributing to therapy optimization using systems and control methods constitutes a great challenge in systems medicine, whose results are expected to have high social and economic impact. The goal of this project is to develop methods for medical treatment optimization, by using the integration of all patient information and features, thus providing quantitative guidelines for personalized bone metastasis treatment, minimizing its toxicity and side effects. IS4 collaborated in the tasks of .